Danish firm expects to sell smallpox vaccine to US

first_imgApr 18, 2007 (CIDRAP News) – Bavarian Nordic, a Danish company, announced this week that the US government plans to buy 20 million doses of the company’s Imvamune smallpox vaccine, but a US official said no decision has been made yet.Imvamune is Bavarian’s version of modified vaccinia Ankara (MVA), which is considered safer than the conventional smallpox vaccine, particularly for people with weakened immune systems, pregnant women, and children.”Following a competitive RFP process, Bavarian Nordic has received notification from the US Department of Health and Human Services that it intends to procure 20 million doses of the company’s third-generation IMVAMUNE smallpox vaccine for the strategic national stockpile,” the company said in an Apr 16 statement.But Holly Babin, an HHS spokeswoman in Washington, DC, said no decision has been made on the vaccine. “We can’t comment on it now,” she told CIDRAP News, but added that an announcement is expected within the next few weeks.Bavarian Nordic and the British drug company Acambis each received an HHS contract in early 2003 to develop and test a vaccine based on MVA. In September 2004 HHS awarded each company a further contract calling for production of 500,000 doses of the vaccine and clinical trials. But Acambis announced in November 2006 that HHS had notified it that the company’s vaccine was too expensive.Bavarian said the expected HHS contract would require the company to win US Food and Drug Administration approval for use of the vaccine in healthy people and those with limited immunity.Peter Wulff, Bavarian’s chief executive officer, said the company plans to begin phase 3 clinical trials early in 2008 and expects to win a US license for the vaccine in 2010, according to an Apr 16 Bloomberg News story.”While the principal terms of the agreement [with HHS] have been reached, the contract is currently being finalized,” the company statement said. “It is expected to be the first procurement contract under the BioShield program since enactment of the Pandemic and All-Hazards Preparedness Act in December 2006.”Bavarian said it has built a facility that can produce at least 40 million doses of Imvamune annually.The BioShield program was established in 2004 to promote the development of medical treatments for the effects of chemical, biological, and other unconventional weapons. But major drug companies showed little interest in the program. In passing the All-Hazards Preparedness Act in December, Congress tried to revitalize the program by authorizing partial payments to companies working under BioShield contracts before final delivery of their products.Existing smallpox vaccines are made with live vaccinia virus—a cousin of the smallpox virus—which in rare cases can cause serious or life-threatening side effects such as a severe rash or encephalitis. MVA is a strain of vaccinia that cannot replicate inside human cells and therefore cannot cause a severe or spreading infection, HHS has said.An MVA-based vaccine was found to be safe when it was given to 120,000 Germans in the 1970s, according to HHS. But research on MVA ended when smallpox was declared eradicated in 1980.Although smallpox was eradicated, disease experts fear that terrorists may have supplies of the virus, which the Soviet Union made in large quantities during the Cold War. Since 2001, HHS has stockpiled enough doses of the conventional smallpox vaccine to immunize the entire US population. The United States and Russia still hold samples of the smallpox virus for research purposes.See also:Oct 4, 2004, CIDRAP News story “Further contracts awarded for weakened smallpox vaccine”Feb 25, 2003, CIDRAP News story “HHS awards contracts to develop safer smallpox vaccine”Dec 15, 2006, CIDRAP News story “Congress passes public health preparedness bill”last_img read more

DPS to roll out TipSubmit cell app Saturday

first_imgIn an effort to improve security on campus, the Dept. of Public Safety plans to unveil a new smart phone application Saturday for reporting anonymous tips about disorderly conduct or crimes.Submit · The app sends anonymous tips directly to the Dept. of Public Safety. – Photo Illuustration by David LowensteinTipSubmit is specifically intended for use during football games and will be unveiled before the first football game of the year, DPS Capt. David Carlisle said. It is only available for Android phones and iPhones.Carlisle said it will be easier to use than the current anonymous tip service, Trojans Care 4 Trojans, which allows students to call or text both a communications center that forwards messages to relevant organizations in the USC community.The new app also serves thousands of communities, universities and law enforcement agencies around the country, including the University of California San Diego, California Polytechnic State University in San Luis Opisbo and Los Angeles City College.The new app will allow users to contact DPS directly with information. It is formatted so users can also see if an incident has already been reported to DPS.“We think the easier we make it, the more people will use it,” Carlisle said. “It is more likely people will use [the new system].”Some students said taking pictures of someone might look strange.“It may look kind of suspicious if you start taking pictures of an incident,” said Kevin Koeller, a freshman majoring in business administration. “Plus it might make things worse if someone sees you taking pictures of them.”Several students also said they believed having this smart phone application would allow more incidents to be reported.“Our generation is very hands-on and connected,” said Dani Haberman, a sophomore majoring in theatre. “[Having the app] at your fingertips will incline more people to report incidents.”The app eliminates the need to use the current anonymous tip service through text messages or by telephone, which many students do not utilize.“More people will use the app, because it seems like it will be very fast and easy,” said Monroe Ekilah, a sophomore majoring in computer engineering and computer science. “I haven’t sent in an anonymous tip because I don’t know the number [for Trojans Care 4 Trojans].”The photo feature on the app will instantly provide DPS with photographical evidence for neutralizing incidents.“[I believe] the ability to submit photographs will be helpful for DPS,” said Karina Garcia, a senior majoring in Spanish. “[It] will allow DPS to know about the incident beforehand and how [they should] handle it.”TipSubmit is available for free download on application markets.last_img read more